Opana ER (oxymorphone extended-release) is a powerful opioid medication used to manage severe, around-the-clock pain in patients who are already opioid-tolerant. Due to its potency and risk for abuse, purchasing Opana ER online must be approached with extreme caution. It's essential to obtain this medication only through licensed and verified pharmacies that comply with federal and state regulations. Always ensure a valid prescription from a licensed healthcare provider is required before purchase, as legitimate pharmacies will never sell controlled substances without one.